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The anti-stress effect by the treatment of vitamin C was investigated in this study. The treatment of ascorbic acid in the presence of Cuz+ion induced strong time- and dose-dependent degradation of hitamine, and also the addition of histamine accelerated time-dependent decomposition of ascorbic acid in vitro. The treatment of ascorbic acid in ODS °d/,, rats, which cannot synthesize ascorbic acid, significantly decreased the urinary histamine. The pretreatment of ascorbic acid, dexamethasone and promethazine inhibited the lethal effect induced by immobilization stress, but that of dimethylsulfoxide did not. The addition of ascorbic acid to a culture of spleen cells of ODS ud/, rats significantly increased the Con A-dependent T lymphocyte proliferation.
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